Overview
Helen M. Pettinati, Allen Zweben, Margaret E. Mattson (JSA Sup 15: 5)
Section 1: Conceptual and Methodological Foundations of COMBINE
Margaret E. Mattson (JSA Sup 15: 6)
Combining Treatments for Alcoholism: Why and How?
Margaret E. Mattson, Raye Z. Litten (JSA Sup 15: 8)
When Worlds Collide: Blending the Divergent Traditions of Pharmacotherapy and Psychotherapy Outcome Research
William R. Miller, Joseph S. LoCastro, Richard Longabaugh, Stephanie O'Malley, Allen Zweben (JSA Sup 15: 17)
Factorial Designs in Clinical Trials: Options for Combination Treatment Studies
David J. Couper, James D. Hosking, Ron A. Cisler, David R. Gastfriend, Daniel R. Kivlahan (JSA Sup 15: 24)
Section 2: Methodological Aspects of the Design of the COMBINE Study
David J. Couper, Raymond F. Anton (JSA Sup 15: 33)
Design and Analysis of Trials of Combination Therapies
James D. Hosking, Ron A. Cisler, David J. Couper, David R. Gastfriend, Daniel R. Kivlahan, Raymond F. Anton (JSA Sup 15: 34)
Use of a “Psychotherapy with No Pills” Treatment Condition as Part of a Combined Pharmacotherapy- Psychotherapy Research Study of Alcohol Dependence
Roger D. Weiss, Joseph S. LoCastro, Robert Swift, Allen Zweben, William R. Miller, Richard Longabaugh, James D. Hosking (JSA Sup 15: 43)
Cost Methodology of COMBINE
Gary A. Zarkin, Jeremy W. Bray, Debanjali Mitra, Ron A. Cisler, Daniel R. Kivlahan (JSA Sup 15: 50)
COMBINE Genetics Study: The Pharmacogenetics of Alcoholism Treatment Response: Genes and Mechanisms
David Goldman, Gabor Oroszi, Stephanie O'Malley, Raymond Anton (JSA Sup 15: 56)
Section 3: Implementing and Monitoring Multisite Randomized Clinical Trials Combining Medications and Psychotherapy
Carrie L. Randall (JSA Sup 15: 65)
How Pilot Studies Improve Large-Scale Clinical Trials: Lessons Learned from the COMBINE Study
Stephanie S. O'Malley, Daniel J. Martin, James D. Hosking, Barbara J. Mason (JSA Sup 15: 66)
Recruiting and Retaining Participants in a Combined Behavioral and Pharmacological Clinical Trial
Allen Zweben, David Barrett, Lisa Berger, Kelly Tobin Murray (JSA Sup 15: 72)
Coordinating and Monitoring Multisite Clinical Trials that Combine Pharmacological and Behavioral Treatments
Marston E. Youngblood, Kelly T. Murray, Eric Devine, Patricia K. Latham, Sandra Hubatch (JSA Sup 15: 82)
Section 4: Assessment in Combined Pharmacotherapy and Behavior Therapy Trials of Alcoholism Treatment: Issues and Domains
Dennis Donovan (JSA Sup 15: 92)
Developing a Baseline Assessment Battery: Balancing Patient Time Burden with Essential Clinical and Research Monitoring
David R. Gastfriend, Dennis Donovan, Rachel Lefebvre, Kelly T. Murray (JSA Sup 15: 94)
Measurement and Choice of Drinking Outcome Variables in the COMBINE Study
Raymond F. Anton, Carrie L. Randall (JSA Sup 15: 104)
Assessing Nondrinking Outcomes in Combined Pharmacotherapy and Psychotherapy Clinical Trials for the Treatment of Alcohol Dependence
Ron A. Cisler, Daniel R. Kivlahan, Dennis Donovan, Margaret E. Mattson (JSA Sup 15: 110)
Quality of Life as an Outcome Measure in Alcoholism Treatment Research
Dennis Donovan, Margaret E. Mattson, Ron A. Cisler, Richard Longabaugh, Allen Zweben (JSA Sup 15: 119)
Section 5: Pharmacological Treatment Selection, Preparation and Monitoring Safety and Compliance
Robert Swift (JSA Sup 15: 140)
Choosing Pharmacotherapies for the COMBINE Study— Process and Procedures: An Investigational Approach to Combination Pharmacotherapy for the Treatment of Alcohol Dependence
Robert Swift, Helen M. Pettinati (JSA Sup 15: 141)
Rationale for Combining Acamprosate and Naltrexone for Treating Alcohol Dependence
Barbara J. Mason (JSA Sup 15: 148)
The COMBINE SAFTEE: A Structured Instrument for Collecting Adverse Events Adapted for Clinical Studies in the Alcoholism Field
Bankole A. Johnson, Nassima Ait-Daoud, John D. Roache (JSA Sup 15: 157)
Section 6: Behavioral Interventions
Richard Longabaugh (JSA Sup 15: 168)
A Structured Approach to Medical Management: A Psychosocial Intervention to Support Pharmacotherapy in the Treatment of Alcohol Dependence
Helen M. Pettinati, Roger D. Weiss, William Dundon, William R. Miller, Dennis Donovan, Denise B. Ernst, Bruce J. Rounsaville (JSA Sup 15: 170)
Origins, Issues and Options in the Development of the Combined Behavioral Intervention
Richard Longabaugh, Allen Zweben, Joseph S. LoCastro, William R. Miller (JSA Sup 15: 179)
Training, Supervision and Quality Monitoring of the COMBINE Study Behavioral Interventions
William R. Miller, Theresa B. Moyers, Lisa Arciniega, Denise Ernst, Alyssa Forcehimes (JSA Sup 15: 188)
INDEX
(JSA Sup 15: 197)
