Overview
Helen M. Pettinati, Allen Zweben, Margaret E. Mattson (JSAD Sup: 5)
Section 1: Conceptual and Methodological Foundations of COMBINE
Margaret E. Mattson (JSAD Sup: 6)
Combining Treatments for Alcoholism: Why and How?
Margaret E. Mattson, Raye Z. Litten (JSAD Sup: 8)
When Worlds Collide: Blending the Divergent Traditions of Pharmacotherapy and Psychotherapy Outcome Research
William R. Miller, Joseph S. Locastro, Richard Longabaugh, Stephanie O'Malley, Allen Zweben (JSAD Sup: 17)
Factorial Designs in Clinical Trials: Options for Combination Treatment Studies
David J. Couper, James D. Hosking, Ron A. Cisler, David R. Gastfriend, Daniel R. Kivlahan (JSAD Sup: 24)
Section 2: Methodological Aspects of the Design of the COMBINE Study
David J. Couper, Raymond F. Anton (JSAD Sup: 33)
Design and Analysis of Trials of Combination Therapies
James D. Hosking, Ron A. Cisler, David J. Couper, David R. Gastfriend, Daniel R. Kivlahan, Raymond F. Anton (JSAD Sup: 34)
Use of a “Psychotherapy with No Pills” Treatment Condition as Part of a Combined Pharmacotherapy- Psychotherapy Research Study of Alcohol Dependence
Roger D. Weiss, Joseph S. Locastro, Robert Swift, Allen Zweben, William R. Miller, Richard Longabaugh, James D. Hosking (JSAD Sup: 43)
Cost Methodology of COMBINE
Gary A. Zarkin, Jeremy W. Bray, Debanjali Mitra, Ron A. Cisler, Daniel R. Kivlahan (JSAD Sup: 50)
COMBINE Genetics Study: The Pharmacogenetics of Alcoholism Treatment Response: Genes and Mechanisms
David Goldman, Gabor Oroszi, Stephanie O'Malley, Raymond Anton (JSAD Sup: 56)
Section 3: Implementing and Monitoring Multisite Randomized Clinical Trials Combining Medications and Psychotherapy
Carrie L. Randall (JSAD Sup: 65)
How Pilot Studies Improve Large-Scale Clinical Trials: Lessons Learned from the COMBINE Study
Stephanie S. O'Malley, Daniel J. Martin, James D. Hosking, Barbara J. Mason (JSAD Sup: 66)
Recruiting and Retaining Participants in a Combined Behavioral and Pharmacological Clinical Trial
Allen Zweben, David Barrett, Lisa Berger, Kelly Tobin Murray (JSAD Sup: 72)
Coordinating and Monitoring Multisite Clinical Trials that Combine Pharmacological and Behavioral Treatments
Marston E. Youngblood, Kelly T. Murray, Eric Devine, Patricia K. Latham, Sandra Hubatch (JSAD Sup: 82)
Section 4: Assessment in Combined Pharmacotherapy and Behavior Therapy Trials of Alcoholism Treatment: Issues and Domains
Dennis Donovan (JSAD Sup: 92)
Developing a Baseline Assessment Battery: Balancing Patient Time Burden with Essential Clinical and Research Monitoring
David R. Gastfriend, Dennis Donovan, Rachel Lefebvre, Kelly T. Murray (JSAD Sup: 94)
Measurement and Choice of Drinking Outcome Variables in the COMBINE Study
Raymond F. Anton, Carrie L. Randall (JSAD Sup: 104)
Assessing Nondrinking Outcomes in Combined Pharmacotherapy and Psychotherapy Clinical Trials for the Treatment of Alcohol Dependence
Ron A. Cisler, Daniel R. Kivlahan, Dennis Donovan, Margaret E. Mattson (JSAD Sup: 110)
Quality of Life as an Outcome Measure in Alcoholism Treatment Research
Dennis Donovan, Margaret E. Mattson, Ron A. Cisler, Richard Longabaugh, Allen Zweben (JSAD Sup: 119)
Section 5: Pharmacological Treatment Selection, Preparation and Monitoring Safety and Compliance
Robert Swift (JSAD Sup: 140)
Choosing Pharmacotherapies for the COMBINE Study— Process and Procedures: An Investigational Approach to Combination Pharmacotherapy for the Treatment of Alcohol Dependence
Robert Swift, Helen M. Pettinati (JSAD Sup: 141)
Rationale for Combining Acamprosate and Naltrexone for Treating Alcohol Dependence
Barbara J. Mason (JSAD Sup: 148)
The COMBINE SAFTEE: A Structured Instrument for Collecting Adverse Events Adapted for Clinical Studies in the Alcoholism Field
Bankole A. Johnson, Nassima Ait-Daoud, John D. Roache (JSAD Sup: 157)
Section 6: Behavioral Interventions
Richard Longabaugh (JSAD Sup: 168)
A Structured Approach to Medical Management: A Psychosocial Intervention to Support Pharmacotherapy in the Treatment of Alcohol Dependence
Helen M. Pettinati, Roger D. Weiss, William Dundon, William R. Miller, Dennis Donovan, Denise B. Ernst, Bruce J. Rounsaville (JSAD Sup: 170)
Origins, Issues and Options in the Development of the Combined Behavioral Intervention
Richard Longabaugh, Allen Zweben, Joseph S. Locastro, William R. Miller (JSAD Sup: 179)
Training, Supervision and Quality Monitoring of the COMBINE Study Behavioral Interventions
William R. Miller, Theresa B. Moyers, Lisa Arciniega, Denise Ernst, Alyssa Forcehimes (JSAD Sup: 188)
INDEX
(JSAD Sup: 197)
