Download this article now for $15.00.
Spiperone Binding Capacity in Lymphocytes of Patients with Alcohol- and Drug-Induced Psychosis: Preliminary Results
Michael Soyka, Brigitta Bondy, Birgit Peuker, Manfred Ackenheil
An increased Spiperone binding capacity in lymphocytes has been proposed as a possible biological marker for schizophrenia while in previous studies patients with alcohol dependence were shown to have a normal binding capacity. In a pilot study the Spiperone binding capacity was studied in 8 patients with alcohol hallucinosis, 11 patients with acute drug-induced psychosis and 12 patients with other organic psychosis. An increased binding capacity, defined as >4 fmol/1 E6 cells, was found in only 1 patient with alcohol hallucinosis, 3 patients with drug-induced psychosis and 2 patients with other organic psychosis. Possible implications of these findings for future research are discussed. (J. Stud. Alcohol 55: 503-507, 1994)
