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Reevaluation of the Disulfiram–Alcohol Reaction in Man

A. M. Sauter, D. Boss, J.-P. von Wartburg

SUMMARY. The intensity of the disulfiram-alcohol reaction is found to depend on the blood acetaldehyde level, a disulfiram-induced predisposition reflected by alkalosis, and an individual predisposition reflected by dopamine-β-hydroxylase activity.