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Multisite Clinical Trials in Alcoholism Treatment Research: Organizational, Methodological and Management Issues
Richard K. Fuller, Margaret E. Mattson, John P. Allen, Carrie L. Randall, Raymond F. Anton, Thomas F. Babor
Multisite clinical trials have two major advantages over single-site studies: the large sample size of multisite studies allows for adequate statistical power and better representativeness of the population being studied. However, they are more complex to implement than single-site studies. This article reviews previous multisite clinical trials of alcohol abuse and alcoholism, reasons for selecting a multisite design, management of such studies, and some statistical issues.
