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Effects of Acamprosate on Memory in Healthy Young Subjects
U. Schneider, K. Wohlfarth, A. Schulze-Bonhage, T. Haacker, K.R. Müller-Vahl, M. Zedler, H. Becker, R. Dengler, H.M. Emrich
Objective: Several studies have shown acamprosate (calciumacetylhomotaurinate) to increase abstinence rates in weaned alcoholics. Chronic alcoholics often suffer from cognitive deficits. Since acamprosate appears to interact with N-methyl-D-aspartate (NMDA) receptors, a subclass of glutamate receptors playing an important role in learning and memory processes, this study was performed in order to investigate different cognitive functions during administration of acamprosate. Method: A randomized, double-blind, cross-over, placebocontrolled design, involving 12 healthy male volunteers was used. Acamprosate 2g daily per os or placebo were administered for 7 days respectively, with a wash-out interval of 21 days between phases. Mood and different memory functions (i.e., working memory, delayed recall, recognition tasks) were assessed. Results: It was shown that a dose of acamprosate 2g/day for 7 days may produce an impairment in delayed free recall. Recognition tasks, short term working memory and mood were not altered. Conclusions: The present study supports the hypothesis that acamprosate impairs memory functions. This is in keeping with the concept of acamprosate acting as NMDA receptor antagonist. The limitations of the study are discussed. (J. Stud. Alcohol 60: 172-175, 1999)
