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Association and Linkage between Alcoholism and Eleven Serological Markers
Shirley Y. Hill, Donald W. Goodwin, Remi Cadoret, C. Kirk Osterland, Sally M. Doner
SUMMARY. Sera from alcoholics and their nonalcoholic first-degree relatives were analyzed for 11 serological markers. A lower prevalence of the S antigen in the nonalcoholic relatives and linkage in repulsion between the D gene of the Rh system and alcoholism were found. All the alcoholics and the relatives had an SS phenotype, when analyzed for complement C3, compared with a prevalence rate of about 50% in other studies. The first two associations involve blood groups, the latter a serum protein.
