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A Simple Cannulation Technique for Determination of Accurate Blood Ethanol Clearance Rates in Rats

Terence J. Braggins, Kathryn E. Crow

SUMMARY. A simple cannulation technique for obtaining posthepatic venous blood from unrestrained rats is described. Ethanol clearance curves determined using blood sampled via the cannula give an accurate measure of the rate of ethanol metabolism in rats in vivo.